The following demands, amongst others, should be made on dry eye treatment:
Preservatives, which prevent the contamination of eye drops during storage and use, can have a negative effect on the tear film. In addition, they can damage the cells of the ocular surface and are the cause of many intolerance reactions.
The EvoTears® products do not contain any preservatives!
In addition to preservatives, however, phosphates, which are often added to eye drops, can also have a negative effect on an already damaged cornea. Phosphates are added to eye drops in order to stabilise the pH.
The problem is that damaged ocular surface cells release calcium, which can combine with the phosphate of eye drops to poorly soluble corneal calcifications. The latter permanently impair vision.
Therefore, eye drops for the treatment of dry, irritated eyes should not contain phosphate.
The EvoTears® products are phosphate-free!
Emulsifiers are added to oil-in-water preparations to allow the mixture and stabilisation of the two, by nature immiscible, phases. Conventional eye drops intended to restore the lipid layer of the tear film usually contain, in addition to water, lipids such as triglycerides, phospholipids or castor oil and thus represent oil-in-water preparations. In order to homogenise or rather stabilise the latter emulsifiers are often added.
The EvoTears® products do not require any emulsifiers thanks to being water-free!
EvoTears® and EvoTears® OMEGA are also characterised by
The EvoTears® products are the first products in the treatment of dry eyes that contain perfluorohexyloctane. Perfluorohexyloctane has already been used for many years in eye surgery, e.g. as a vitreous replacement. With EvoTears® and EvoTears® OMEGA it is now available for the first time as eye drops.
EvoTears® and EvoTears® OMEGA contain perfluorohexyloctane as pure or main substance respectively and are therefore anhydrous. Therefore, the products do not require any additives such as preservatives, emulsifiers or phosphates.
Thanks to the absence of water, there is no need for preservatives, as microorganisms depend on water for their survival. In addition, due to the absence of water, the EvoTears® products have neither a pH nor osmolarity. If water-containing eye drops have a pH and/or osmolarity ouside the physiological range, intolerance reactions are possible, such as burning or hypertonic stress that can cause inflammation.
Thanks to perfluorohexyloctane, the surface tension of EvoTears® and EvoTears® OMEGA is much lower than that of water. This is why the eye drops spread quickly over the tear forming a unique protective layer. In addition, a very small drop is dispensed (approx. 10 µl compared to a water-containing drop of 40 – 50 µl), the volume of which corresponds to the capacity of the conjunctival sac. This ensures a pleasant application as little or no product will run out of the eye.
The small drop volume ensures a high yield. The 3 ml content allows the delivery of up to 280 drops, thus about 4 times as many drops as from a comparable volume of water-containing tear substitutes.
The lipophilic (fat-loving) properties of perfluorohexyloctane allow the EvoTears® products to take over the function of the lipid layer. The resulting effective protection against evaporation leads to patient satisfaction. In addition, the aqueous phase of the tear film is stabilised and watery eyes are prevented.
Thanks to the lipophilic property a velvet-like feeling occurs when the drop spreads over the ocular surface.
Thanks to perfluorohexyloctane, the EvoTears® products remain on the ocural surface for a long time and therefore protect the tear film from evaporation. As a rule, a low application frequency of 2 to 4 times a day is sufficient. Thus, a bottle containing 3 ml offers a treatment duration of 35 days with a 4-times daily application*. If an application* is only required twice a day, the bottle is sufficient for 70 treatment days!
* Application corresponds to one drop per eye
The innovative substance perfluorohexyloctane is lipophilic (fat-loving), but has the same refractive index as tears. Therefore, the EvoTears® products do not affect vision.