The innovation in the treatment of dry eyes

The first eye drops to contain perfluorohexyloctane and also the first water-free drops in the treatment of dry eyes.

The unique* lipid replacement

EvoTears® and EvoTears® OMEGA are the world’s first eye drops with the innovative substance perfluorohexyloctane and also the first water-free drops for the treatment of dry eyes. They are offered in a handy dropper bottle.

The EvoTears® products form a protective layer over the tear film. Consequently, they quickly and reliably prevent premature evaporation of the tear film and thus dry eyes. At the same time, vision is not impaired. As the products are free of additives they are very well tolerated.

Dry eyes are caused, for instance

  • by a compromised lipid layer, i.e. premature evaporation of the tear film. In 58 % of dry eye patients this is the sole cause1,
  • by a combination of compromised lipid layer and volume deficiency. This affects
    31 % of dry eye patients.

Because the EvoTears® products specifically address the problem with the lipid layer, they are suitable for almost 90 % of dry eye patients.

* due to perfluorohexyloctane and being water-free.

1 Tong L et al. Invest Ophthalmol Yis Sci, 2010. 51: 3449-3454

 

The EvoTears® products convince with decisive advantages:

1. EvoTears® and EvoTears® OMEGA take on the function of the lipid layer

The lipophilic, i.e. oil-like property of perfluorohexyloctane allows it to take on the function of the lipid layer. The resulting effective protection against evaporation leads to patient satisfaction. In addition, the aqueous phase of the tear film is stabilised and watery eyes are prevented.
Thanks to the lipophilic property, a velvet-like feeling occurs when the drop spreads over the ocular surface.

2. Rapid spreading over the tear

Due to the low surface tension of perfluorohexyloctane, the drop spreads rapidly and quickly forms a protective layer over the tear film

3. High yield

The extremely low surface tension leads to the dispensing of a very small drop (about 10 μl). Consequently, with up to 280 drops per 3 ml content the product has a very high yield. In addition the drop volume corresponds to the capacity of the conjunctival sac. This ensures a pleasant application as little or no product will run out of the eye.

4. Long treatment duration

Thanks to the prolonged ocular retention time, the protection of the eye against evaporation is long-lasting. Combined with the high yield a bottle containing 3 ml offers a treatment duration of 35 or 70 days when applied 4 -times or twice a day respectively.

5. Preservative-free

Due to perfluorohexyloctane, EvoTears® and EvoTears® OMEGA are water-free. Microorganisms on the other hand depend on water for survival. Therefore, the products can be offered in a handy dropper bottle, even without the addition of preservatives.

6. No need for phosphates

The EvoTears® products, being water-free, do not have a pH and therefore do not need to be buffered. A pH outside the physiological range can cause a burning sensation. As buffer phosphate-containing compounds are often used, which, on an irritated ocular surface can lead to damage and thus visual impairment.

7. No need for emulsifiers

As EvoTears® and EvoTears® OMEGA are not oil-in-water-mixtures there is no need for emulsifiers.

8. No visual impairment

The refractive index of EvoTears® and EvoTears® OMEGA is equal to that of the tear and therefore they cannot impair vision.

9. No osmotic stress

Due to being water-free the EvoTears® products have no osmolarity. This prevents the ocular surface from being subjected to osmotic stress that can cause inflammation.